Preliminary exploration of the application of cyanoacrylate glue in Forrest IIa and IIb peptic ulcer hemorrhage.

IF 2.7 2区医学 Q2 SURGERY Surgical Endoscopy And Other Interventional Techniques Pub Date : 2025-05-01 Epub Date: 2025-04-08 DOI:10.1007/s00464-025-11702-8

Ye Ye, Luojie Liu, Liansheng Xu

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Abstract

Objective: This study aims to preliminarily investigate the therapeutic effect of cyanoacrylate glue (CG) on Forrest IIa and IIb peptic ulcer hemorrhage (PCH).

Methods: From January 2020 to May 2024, we retrospectively collected data on patients with Forrest IIa and IIb PCH treated with CG using emergency endoscopic hemostasis at a single center and subsequently evaluated and compared the efficacy of CG with respect to ulcer location, Forrest staging, and ulcer size.

Results: A total of 93 patients were enrolled, achieving 100% technical success without 24-h rebleeding. The rebleeding rate at 72 h was 1.1% (95% confidence interval [CI]: 0.2-5.9%), and the rebleeding rate at 7 days was 2.2% (95% CI: 0.6-7.6%). The median age of the patients was 43.0 years. There were 42 patients (45.2%) with Forrest IIa ulcers and 51 patients (54.8%) with Forrest IIb ulcers. Sixty patients (64.5%) had ulcers ranging in size from 1.0 to 2.0 cm, while 33 patients (35.5%) had ulcers larger than 2.0 cm. The ulcers were located in the antrum (19 cases), angulus (38 cases), gastric body (11 cases), and duodenal bulb (25 cases). Median procedure time was 12.0 min, with duodenal PCH requiring significantly less time than stomach PCH (P < 0.05). CG treatment efficacy was comparable between Forrest IIa/IIb ulcers as well as across ulcer sizes (P > 0.05).

Conclusions: CG is particularly effective and safe for PCH located in the duodenal bulb, as well as for both Forrest IIa and IIb PCH.

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在 Forrest IIa 和 IIb 消化性溃疡出血中应用氰基丙烯酸酯胶的初步探索。

目的：初步探讨氰基丙烯酸酯胶（CG）对消化性溃疡出血（PCH）的治疗作用。方法：从2020年1月至2024年5月，我们回顾性收集了在单一中心使用急诊内镜止血的CG治疗的Forrest IIa和IIb PCH患者的数据，随后评估和比较CG在溃疡位置、Forrest分期和溃疡大小方面的疗效。结果：共纳入93例患者，技术成功率100%，无24小时再出血。72 h再出血率为1.1%(95%可信区间[CI]: 0.2-5.9%)， 7 d再出血率为2.2% （95% CI: 0.6-7.6%）。患者中位年龄为43.0岁。42例（45.2%）为Forrest IIa溃疡，51例（54.8%）为Forrest IIb溃疡。60例（64.5%）患者溃疡大小在1.0 ~ 2.0 cm之间，33例（35.5%）患者溃疡大于2.0 cm。溃疡位于胃窦（19例）、胃角（38例）、胃体（11例）和十二指肠球部（25例）。中位手术时间为12.0 min，十二指肠PCH所需时间明显少于胃PCH （p0.05）。结论：对于位于十二指肠球部的PCH，以及Forrest IIa和IIb PCH， CG特别有效和安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Endoscopy And Other Interventional Techniques 医学-外科

CiteScore

6.10

自引率

12.90%

发文量

890

审稿时长

6 months

期刊介绍： Uniquely positioned at the interface between various medical and surgical disciplines, Surgical Endoscopy serves as a focal point for the international surgical community to exchange information on practice, theory, and research. Topics covered in the journal include: -Surgical aspects of: Interventional endoscopy, Ultrasound, Other techniques in the fields of gastroenterology, obstetrics, gynecology, and urology, -Gastroenterologic surgery -Thoracic surgery -Traumatic surgery -Orthopedic surgery -Pediatric surgery