Prognostic value of myocardial flow reserve by PET imaging in patients with suspected coronary artery disease: A systematic review and meta-analysis

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS IJC Heart and Vasculature Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI:10.1016/j.ijcha.2025.101677

Adriana D’Antonio , Roberta Assante , Emilia Zampella , Valeria Cantoni , Roberta Green , Valeria Gaudieri , Teresa Mannarino , Maria Falzarano , Federica Volpicelli , Paolo Cutillo , Francesca Matrisciano , Pietro Buongiorno , Mariarosaria Panico , Carmela Nappi , Domenico Cozzolino , Mario Petretta , Alberto Cuocolo , Wanda Acampa

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Abstract

Purpose

We performed a systematic review and meta-analysis of published studies evaluating the value of myocardial flow reserve (MFR) assessed by positron emission tomography (PET) imaging in predicting adverse cardiovascular events in patients with suspected coronary artery disease (CAD).

Material and methods

Studies published until December 2024 were identified by database search. We included studies evaluating MFR by PET imaging with data on adjusted hazard ratio (HR) for the occurrence of adverse cardiovascular events.

Results

We identified 8 eligible articles including 12.087 patients with a mean follow-up of 2.98 ± 0.69 years. The pooled HR for the occurrence of events was 2.19 (95 % CI 1.80–2.68) and no heterogeneity was observed. The pooled incidence rate ratio (IRR) was 3.26 (95 % CI 2.43–4.37) and the heterogeneity was 37.7 %. At meta-regression analysis no significant association was found between HR for adverse events and demographic and clinical variables considered.

Conclusion

MFR assessed by PET imaging is a valuable noninvasive prognostic indicator in the evaluation of patients with suspected CAD.

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PET显像对疑似冠状动脉疾病患者心肌血流储备的预后价值：一项系统回顾和荟萃分析

目的：对已发表的研究进行系统回顾和荟萃分析，以评估正电子发射断层扫描（PET）评估心肌血流储备（MFR）在预测疑似冠状动脉疾病（CAD）患者不良心血管事件中的价值。材料和方法通过数据库检索确定2024年12月之前发表的研究。我们纳入了通过PET成像评估MFR的研究，并提供了不良心血管事件发生的校正危险比（HR）数据。结果纳入8篇符合条件的文献，包括12.087例患者，平均随访时间为2.98±0.69年。事件发生的总风险比为2.19 (95% CI 1.80-2.68)，未观察到异质性。合并发病率比（IRR）为3.26 (95% CI 2.43-4.37)，异质性为37.7%。在荟萃回归分析中，没有发现不良事件的HR与人口学和临床变量之间存在显著关联。结论PET显像评价mfr是评价疑似CAD患者有价值的无创预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.