Recent advances in direct asymmetric reaction of furanone

Abstract

Butenoic acid compounds or γ-butyrolactone compounds containing multiple chiral centers widely exist in various natural products and have very important biological activities, such as anti-tumor activity. However, the scarcity of many highly active natural compounds restricts their potential for further research into biological functions and therapeutic applications. Therefore, new methods are required for the efficient synthesis of these compounds. Direct catalytic asymmetric reactions based on furanone have emerged as a promising approach for the quick construction of chiral poly-substituted compounds, enabling the synthesis of biologically active natural products, analogues, and bio-active molecules. In this review, we will explore recent developments in direct catalytic asymmetric reactions based on furanone and their applications in the synthesis of natural products and bioactive molecules.