Visible light-induced perfluoroalkylation reaction of indoles in the presence of Na2-eosin Y

Abstract

Visible light-induced perfluoroalkylation reaction of 3-substituted indoles using Na₂-Eosin Y as photoredox catalysis was achieved under mild conditions to give a series of C2-perfluoroalkylated indoles in moderate to good yields. Under similar conditions, both C3 and C4 perfluoroalkylation reactions of 2-substituted indoles occurred to produce two regioisomers. The reaction of unsubstituted indole gave the C2 and C3 perfluoroalkylation products. A possible pathway was proposed based on the experimental results.