{"title":"Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7-driven Small Cell Lung Cancer (Adv. Sci. 14/2025)","authors":"Tingting Qin, Jingya Wang, Jian Wang, Qingwu Du, Liuchun Wang, Hailin Liu, Wenting Liu, Xueyang Li, Yantao Jiang, Qi Xu, Junjie Yu, Huiyan Liu, Ting Wang, Mengjie Li, Dingzhi Huang","doi":"10.1002/advs.202570096","DOIUrl":null,"url":null,"abstract":"<p><b>New Subtype of Small Cell Lung Cancer</b></p><p>In article number 2413445, Dingzhi Huang, Mengjie Li, and co-workers report that a HDAC7-high small cell lung cancer (SCLC) subtype has a poor prognosis and have identified XPO1 as a druggable target in this subtype. Elevated HDAC7 predicts increased sensitivity to selinexor both in vitro and in organoids, suggesting selinexor as a promising therapeutic option for HDAC7-high SCLC patients.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 14","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570096","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570096","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
New Subtype of Small Cell Lung Cancer
In article number 2413445, Dingzhi Huang, Mengjie Li, and co-workers report that a HDAC7-high small cell lung cancer (SCLC) subtype has a poor prognosis and have identified XPO1 as a druggable target in this subtype. Elevated HDAC7 predicts increased sensitivity to selinexor both in vitro and in organoids, suggesting selinexor as a promising therapeutic option for HDAC7-high SCLC patients.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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