{"title":"Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression (Adv. Sci. 14/2025)","authors":"Jing Wang, Weiqiang Yu, Hui Shen, Yanxiang Sang, Hongjie Zhang, Benyan Zheng, Xue Peng, Yuan Hu, Xiaopeng Ma, Zhenye Yang, Fazhi Yu","doi":"10.1002/advs.202570100","DOIUrl":null,"url":null,"abstract":"<p><b>Cancer Therapy</b></p><p>In article number 2414779, Fazhi Yu and co-workers explore black phosphorus (BP) nanosheets in breast cancer models, showing the ability to inhibit tumor growth. BP-PEG enhances immune responses by promoting neutrophil recruitment and reprogramming tumor-associated neutrophils to an anti-tumor phenotype, boosting both innate and adaptive anti-tumor immune activities. Combining BP therapy with immunotherapies or chemotherapies potentially counteracts neutrophil-induced immunosuppression, restoring or enhancing their therapeutic efficacy.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 14","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570100","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570100","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer Therapy
In article number 2414779, Fazhi Yu and co-workers explore black phosphorus (BP) nanosheets in breast cancer models, showing the ability to inhibit tumor growth. BP-PEG enhances immune responses by promoting neutrophil recruitment and reprogramming tumor-associated neutrophils to an anti-tumor phenotype, boosting both innate and adaptive anti-tumor immune activities. Combining BP therapy with immunotherapies or chemotherapies potentially counteracts neutrophil-induced immunosuppression, restoring or enhancing their therapeutic efficacy.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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