Perspective on enhancing CRC risk prediction

Abstract

We read with great interest the study by Digby et al , which presents an innovative approach towards improving colorectal cancer (CRC) risk stratification by combining faecal haemoglobin (f-Hb), iron-deficiency anaemia (IDA) and age.1 The authors’ recommendations to refine thresholds for referral and optimise colonoscopy resources offer valuable insights. However, several aspects still need to be discussed. First, we commend the effort to combine f-Hb with IDA and age for risk prediction. However, the study relies on a single analyser (HM-JACKarc), which raises questions about the generalisability of findings across different healthcare systems using other platforms …