Zhenxiang Liu , Lingli Shao , Shuping Cai , Chaoqun Bian , Haojie Zhu , Xuanang Shen , Hangcheng Ni , Ling Wang , Kaichuan Yang , Hui Mao
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引用次数: 0
Abstract
An economical and environment-friendly synthetic route was developed toward L-penicillamine (L-H2pen) in concise 8-step from commercially available and inexpensive Penicillin G potassium salt. Ordinary reagents such as acetone, ethanol, triethylamine, L(+)-Tartaric acid etc. are used and no special catalysts applied in whole process. Acetone used in step 2 and D-penicillamine (D-H2pen) produced from resolving process could be recycled after appropriate working up. The total yield of L-H2pen reached around 20 % based on the starting materials. No chromatographic separations were utilized in the new protocol which seems amenable to scale-up.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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