{"title":"Synthesis of a New Class of Functionalized Isoxazole/Isoxazoline Styrylchromone Derivatives","authors":"P. Limbadri, Y. Hemasri","doi":"10.1134/S1070428025020162","DOIUrl":null,"url":null,"abstract":"<p>A simple and practical method of synthesis of a new series of functionalized isoxazole/isoxazoline styrylchromone derivatives from 3-hydroxy-2-styrylchromone <i>via</i> an alkene/alkyne-tethered intermediate by adopting intermolecular 1,3-dipolar cycloaddition of nitrile oxide in the presence of the environmentally safe sodium hypochloride oxidant under mild reaction conditions. The structures of all the synthesized compounds were confirmed by <sup>1</sup>H and <sup>13</sup>C NMR, ESI–MS, and ESI-HRMS.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"312 - 319"},"PeriodicalIF":0.9000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428025020162","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A simple and practical method of synthesis of a new series of functionalized isoxazole/isoxazoline styrylchromone derivatives from 3-hydroxy-2-styrylchromone via an alkene/alkyne-tethered intermediate by adopting intermolecular 1,3-dipolar cycloaddition of nitrile oxide in the presence of the environmentally safe sodium hypochloride oxidant under mild reaction conditions. The structures of all the synthesized compounds were confirmed by 1H and 13C NMR, ESI–MS, and ESI-HRMS.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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