Tailored Therapeutic Approach in a Patient With Diffuse Large B-Cell Lymphoma With Meningeal Infiltration, Concurrent Classic Hodgkin Lymphoma, and Smoldering Multiple Myeloma: A Case Report

IF 1.9 Q4 ONCOLOGY Cancer reports Pub Date : 2025-04-15 DOI:10.1002/cnr2.70102

Giusy Ceparano, Daniele Lorenzini, Maurilio Ponzoni, Giorgia Levati, Davide Epifania, Vincenzo Marasco

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Abstract

Background

Coexisting primary hematologic malignancies in untreated multiple myeloma (MM) are rare.

Case

A 69-year-old man with smoldering multiple myeloma (sMM) presented with lymphadenopathies and an intracranial mass. He was diagnosed with diffuse large B-cell lymphoma (DLBCL), classic Hodgkin lymphoma (cHL), and sMM. The patient received R-CHOP and R-ICE, followed by autologous stem cell transplantation, achieving complete remission of DLBCL and cHL, and very good partial remission of MM.

Conclusion

This case illustrates the complexity of managing multiple malignancies and the importance of a tailored therapeutic approach.

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弥漫大 B 细胞淋巴瘤伴脑膜浸润、并发典型霍奇金淋巴瘤和多发性骨髓瘤患者的定制治疗方法：病例报告

背景：未经治疗的多发性骨髓瘤（MM）并发原发性血液系统恶性肿瘤是罕见的。病例一名69岁男性阴燃性多发性骨髓瘤（sMM），表现为淋巴结病变和颅内肿块。他被诊断为弥漫性大b细胞淋巴瘤（DLBCL），经典霍奇金淋巴瘤（cHL）和sMM。患者接受了R-CHOP和R-ICE，随后进行了自体干细胞移植，实现了DLBCL和cHL的完全缓解，MM的部分缓解非常好。结论该病例说明了治疗多发性恶性肿瘤的复杂性和量身定制治疗方法的重要性。

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