MaDDFLOSY(Mass Determination via Diffusion in FLow Ordered SpectroscopY) for the Determination of Diffusion-Averaged Molecular Weight of Polymers in Continuous Motion Using Benchtop NMR

IF 5.2 1区化学 Q1 POLYMER SCIENCE Macromolecules Pub Date : 2025-04-16 DOI:10.1021/acs.macromol.4c03260

William Pointer, Owen Tooley, Asad Saib, Rowan Radmall, Paul Wilson, Daniel Lester, James Town, Robin J. Blagg, David Haddleton

引用次数: 0

Abstract

Real-time determination of the molecular weight of polymers synthesized in continuous flow or indeed in any process is essential for efficient and sustainable process chemistry. Typically achieved through online chromatographic techniques, such methods are often prone to perturbations, require large volumes of solvents, have lengthy acquisition times, and can result in significant process inefficiencies. We demonstrate the use of diffusion-ordered NMR spectroscopy (DOSY NMR) calibration on a 60 MHz benchtop to measure the molecular weight of polymers while in laminar flow. We then utilized this technique to monitor batch polymerization progress in real time.

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madflosy（通过流动有序光谱中的扩散进行质量测定）用于使用台式核磁共振测定聚合物在连续运动中的扩散平均分子量

实时测定在连续流动或任何过程中合成的聚合物的分子量对于高效和可持续的过程化学是必不可少的。通常通过在线色谱技术实现，这种方法通常容易受到干扰，需要大量溶剂，采集时间长，并且可能导致显着的过程效率低下。我们演示了在60 MHz台式上使用扩散有序核磁共振波谱（DOSY NMR）校准来测量层流中聚合物的分子量。然后利用该技术实时监测间歇聚合过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecules 工程技术-高分子科学

CiteScore

9.30

自引率

16.40%

发文量

942

审稿时长

2 months

期刊介绍： Macromolecules publishes original, fundamental, and impactful research on all aspects of polymer science. Topics of interest include synthesis (e.g., controlled polymerizations, polymerization catalysis, post polymerization modification, new monomer structures and polymer architectures, and polymerization mechanisms/kinetics analysis); phase behavior, thermodynamics, dynamic, and ordering/disordering phenomena (e.g., self-assembly, gelation, crystallization, solution/melt/solid-state characteristics); structure and properties (e.g., mechanical and rheological properties, surface/interfacial characteristics, electronic and transport properties); new state of the art characterization (e.g., spectroscopy, scattering, microscopy, rheology), simulation (e.g., Monte Carlo, molecular dynamics, multi-scale/coarse-grained modeling), and theoretical methods. Renewable/sustainable polymers, polymer networks, responsive polymers, electro-, magneto- and opto-active macromolecules, inorganic polymers, charge-transporting polymers (ion-containing, semiconducting, and conducting), nanostructured polymers, and polymer composites are also of interest. Typical papers published in Macromolecules showcase important and innovative concepts, experimental methods/observations, and theoretical/computational approaches that demonstrate a fundamental advance in the understanding of polymers.