{"title":"Double filtration plasmapheresis in autoimmune gastritis with subacute combined degeneration of the spinal cord: A case report","authors":"Qiuju Li , Bin Liu , Yangtai Guan, Yuhui Wang","doi":"10.1016/j.jneuroim.2025.578618","DOIUrl":null,"url":null,"abstract":"<div><div>Autoimmune gastritis (AIG) is characterized by the destruction of gastric parietal cells, leading to vitamin B12 deficiency and potentially causing subacute combined degeneration of the spinal cord (SCD). We present a case of a 61-year-old male with AIG who developed SCD and underwent three sessions of double filtration plasmapheresis (DFPP), resulting in significant reduction of autoantibody titers and improvement in neurological symptoms. DFPP demonstrated efficacy in treating AIG complicated by SCD, offering potentially faster clinical response than conventional therapies by rapidly reducing autoantibody levels. This case underscores the importance of early diagnosis and intervention in preventing irreversible neurological damage, suggesting DFPP as a promising adjunctive treatment for AIG with SCD and warranting further investigation into its mechanisms and applications in autoimmune diseases.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"403 ","pages":"Article 578618"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neuroimmunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165572825000992","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Autoimmune gastritis (AIG) is characterized by the destruction of gastric parietal cells, leading to vitamin B12 deficiency and potentially causing subacute combined degeneration of the spinal cord (SCD). We present a case of a 61-year-old male with AIG who developed SCD and underwent three sessions of double filtration plasmapheresis (DFPP), resulting in significant reduction of autoantibody titers and improvement in neurological symptoms. DFPP demonstrated efficacy in treating AIG complicated by SCD, offering potentially faster clinical response than conventional therapies by rapidly reducing autoantibody levels. This case underscores the importance of early diagnosis and intervention in preventing irreversible neurological damage, suggesting DFPP as a promising adjunctive treatment for AIG with SCD and warranting further investigation into its mechanisms and applications in autoimmune diseases.
期刊介绍：
The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.
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