Copper-Catalyzed Reductive Hydroamination of Inactive Diarylacetylenes with Nitroarenes

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-04-17 DOI:10.1021/acs.orglett.5c00964

Zhiyou Li, Jie Tang, Xinyue Ma, Long Liu, Mengjie Cen, Qiang Li, Tianzeng Huang, Chunya Li, Tieqiao Chen

引用次数: 0

Abstract

Reductive hydroamination of stable and readily available nitroarenes with unsaturated hydrocarbons represents practical access to amines. Herein, we report a simple Cu-catalyzed amine synthesis via the reductive hydroamination of nitroarenes with inactive diarylacetylenes. A series of diarylacetylenes are successfully transformed into secondary amines under mild conditions with good functional group tolerance.

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铜催化非活性二芳基乙炔与硝基芳烃的还原氢胺化反应

稳定和容易获得的硝基芳烃与不饱和烃的还原性氢胺化反应代表了获得胺的实际途径。在这里，我们报告了一个简单的铜催化胺合成通过硝基芳烃与非活性二芳基乙炔的还原氢胺化。一系列二芳基乙炔在温和的条件下成功转化为仲胺，具有良好的官能团耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.