Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong
{"title":"The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ (Adv. Sci. 15/2025)","authors":"Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong","doi":"10.1002/advs.202570108","DOIUrl":null,"url":null,"abstract":"<p><b>Fetal Growth Restriction</b></p><p>Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus participate in the transcriptional regulation of downstream genes, which is not identical to that of endogenous PPARγ in preadipocytes. Compromised PPARγ in the placenta causes deficient adipogenesis in the fetus and intruterine growth restriction but can be rescued by placenta-targeted activation of PPARγ. More details can be found in article number 2404983 by Hongbo Qi, Chao Tong, and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570108","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570108","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Fetal Growth Restriction
Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus participate in the transcriptional regulation of downstream genes, which is not identical to that of endogenous PPARγ in preadipocytes. Compromised PPARγ in the placenta causes deficient adipogenesis in the fetus and intruterine growth restriction but can be rescued by placenta-targeted activation of PPARγ. More details can be found in article number 2404983 by Hongbo Qi, Chao Tong, and co-workers.
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Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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