Cover Feature: The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead (ChemMedChem 8/2025)

IF 3.4 4区医学 Q2 CHEMISTRY, MEDICINAL ChemMedChem Pub Date : 2025-04-17 DOI:10.1002/cmdc.202580804

Jean Quancard, Anders Bach, Chiara Borsari, Russell Craft, Christian Gnamm, Stéphanie M. Guéret, Ingo V. Hartung, Hannes F. Koolman, Stefan Laufer, Susan Lepri, Josef Messinger, Kurt Ritter, Gianluca Sbardella, Andrea Unzue Lopez, Marina K. Willwacher, Brian Cox, Robert J. Young

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Abstract

“Searching for diamonds in the rough” summarises consensus best practices in how to expedite the processes and enable decision making in the Hits-to-Leads phase of drug discovery. The EFMC Best Practices Group, led by Jean Quancard, draws on expertise from seasoned drug hunters (industrial and academic) from all over Europe, producing open-source educational materials. This paper complements webinars on the topic, part of an expanding series with associated online content (videos of presentations, slides, publications) produced to be open-source educational materials. More details can be found in article 10.1002/cmdc.202400931 by Jean Quancard, Robert J. Young, and co-workers.

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封面特写：欧洲药物化学和化学生物学联合会（EFMC）最佳实践倡议：Hit to Lead （ChemMedChem 8/2025）

“在粗糙中寻找钻石”总结了如何加快流程并使药物发现从成功到成功阶段的决策成为可能的共识最佳做法。由Jean Quancard领导的EFMC最佳实践小组吸收了欧洲各地经验丰富的药物猎人（工业界和学术界）的专业知识，制作了开源的教育材料。这篇论文补充了关于这个主题的网络研讨会，这是一个扩展系列的一部分，它与相关的在线内容（演示视频、幻灯片、出版物）一起被制作成开源的教育材料。更多细节可以在10.1002/cmdc中找到。202400931，作者：Jean Quancard， Robert J. Young及其同事。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.