Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan
{"title":"LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease (Adv. Sci. 15/2025)","authors":"Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan","doi":"10.1002/advs.202570110","DOIUrl":null,"url":null,"abstract":"<p><b>Dysfunction-Associated Steatotic Liver Disease</b></p><p>High-fat diet upregulated O-GlcNAcylation of LIMA1 and LIMA1-enriched small extracellular vesicle (sEV) secretion in hepatocytes, exacerbated hepatic lipid deposition and metabolic dysfunction-associated steato-hepatitis (MASH) fibrosis. LIMA1 is a promising non-invasive biomarker and therapeutic target for MASH. More details can be found in article number 2415941 by Yongmin Yan and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570110","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570110","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Dysfunction-Associated Steatotic Liver Disease
High-fat diet upregulated O-GlcNAcylation of LIMA1 and LIMA1-enriched small extracellular vesicle (sEV) secretion in hepatocytes, exacerbated hepatic lipid deposition and metabolic dysfunction-associated steato-hepatitis (MASH) fibrosis. LIMA1 is a promising non-invasive biomarker and therapeutic target for MASH. More details can be found in article number 2415941 by Yongmin Yan and co-workers.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.