{"title":"Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress-Associated Degradation of EZH2/MYC Axis (Adv. Sci. 15/2025)","authors":"Yin Zhu, Yurui Liu, Xiangtao Wang, Zhifeng Chen, Baojian Chen, Bingxin Hu, Tiane Tang, Haoran Cheng, Xinglong Liu, Yunshan Ning","doi":"10.1002/advs.202570109","DOIUrl":null,"url":null,"abstract":"<p><b>Endoplasmic Reticulum Stress Response</b></p><p>Squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function. These actions provoke endoplasmic reticulum (ER) stress and activate the unfolded protein response within tumor cells. This, in turn triggers the UBA6-UBE2ZFBXW7 ubiquitin cascade, enhancing ER stress-associated ubiquitylation and degradation of EZH2 and MYC, ultimately resulting in tumor growth arrest. More details can be found in article number 2413120 by Yunshan Ning and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 15","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570109","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570109","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Endoplasmic Reticulum Stress Response
Squamocin disrupts mitochondrial respiratory Complex I function, reduces ATP production, and impairs HSP90α function. These actions provoke endoplasmic reticulum (ER) stress and activate the unfolded protein response within tumor cells. This, in turn triggers the UBA6-UBE2ZFBXW7 ubiquitin cascade, enhancing ER stress-associated ubiquitylation and degradation of EZH2 and MYC, ultimately resulting in tumor growth arrest. More details can be found in article number 2413120 by Yunshan Ning and co-workers.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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