Youjie Wang, Chen Ye, Ruosu Pan, Biqiu Tang, Congjun Li, Junfeng Liu, Wendan Tao, Xuening Zhang, Tang Yang, Yuying Yan, Shuai Jiang, Su Lui, Bo Wu
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引用次数: 0
Abstract
INTRODUCTION
Regional brain iron dyshomeostasis is observed in cerebral small vessel disease (cSVD) and other neurodegeneration processes. However, its spatial patterns, cognitive impact, and underlying pathological mechanisms remain unclear.
METHODS
Voxel-based analysis of quantitative susceptibility mapping (QSM) was used to detect regional susceptibility changes, and their correlations with cognitive function were assessed using linear regression. We combined the microarray dataset from the Allen Human Brain Atlas (AHBA) to explore the pathological mechanisms of iron deposition patterns.
RESULTS
A total of 87 cSVD patients and 80 controls were included in the study. Increased QSM values in the bilateral putamen and caudate were associated with cognitive decline in cSVD. Gene set enrichment analysis revealed the enrichment of gene sets related to central nervous system integrity.
DISCUSSION
Iron deposition in deep gray matter may indicate cognitive changes in cSVD and could be linked to the disruption of brain structural and functional integrity.
Highlights
Increased susceptibility values, indicating focal iron deposition, were observed in the deep gray matter of patients with cerebral small vessel disease (cSVD).
Regional iron concentration in the deep gray nuclei was associated with cognitive impairment in cSVD patients.
Imaging transcriptomics suggests that cSVD-related iron deposition is linked to the structural and functional integrity of the brain.
An open-source script for imaging transcriptomics focusing on regional gene expression was developed and proposed.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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