NOX Family: Regulators of Reactive Oxygen Species Balance in Tumor Cells

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY The FASEB Journal Pub Date : 2025-04-23 DOI:10.1096/fj.202500238RRR

Bin Xiong, Yang Zhang, Siyi Liu, Shan Liao, Zihua Zhou, Qian He, Yanhong Zhou

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Abstract

Cancer cells are capable of surviving, proliferating, and invading or migrating within hypoxic environments by regulating various adaptive mechanisms. Due to the activation of oncogenes and the inactivation of tumor suppressor genes, and relative deficiencies in oxygen and nutrients, cancer cells demonstrate elevated production of reactive oxygen species (ROS), primarily sourced from NADPH oxidases (NOX family). A key aspect of the reorientation of tumor cell metabolism is the combating of cellular oxidative stress through the promotion of antioxidant molecule synthesis to counteract ROS production. Given that most cancers experience hypoxia and that NOX is closely linked to numerous redox-dependent signaling pathways, the expression and function of NOX are altered in various malignancies. Therefore, this review summarizes the characteristics of NOX family members, their influence on tumor proliferation, invasion, and migration, the role of NOX in promoting tumor angiogenesis, the impact of NOX on the function of immune cells within the tumor microenvironment, and the potential of targeting NOX in tumor therapy. This aims to offer a fresh viewpoint on a comprehensive understanding of the functions of NOX family members.

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NOX家族：肿瘤细胞中活性氧平衡的调节因子

癌细胞通过调节各种适应机制在缺氧环境中生存、增殖、侵袭或迁移。由于癌基因的激活和抑癌基因的失活，以及氧气和营养物质的相对缺乏，癌细胞表现出活性氧（ROS）的增加，主要来自NADPH氧化酶（NOX家族）。肿瘤细胞代谢重定向的一个关键方面是通过促进抗氧化分子合成来对抗ROS的产生来对抗细胞氧化应激。鉴于大多数癌症经历缺氧，并且NOX与许多氧化还原依赖的信号通路密切相关，NOX的表达和功能在各种恶性肿瘤中发生改变。因此，本文就NOX家族成员的特点、对肿瘤增殖、侵袭和迁移的影响、NOX在促进肿瘤血管生成中的作用、NOX对肿瘤微环境中免疫细胞功能的影响以及NOX靶向肿瘤治疗的潜力进行综述。本文旨在为全面了解NOX家族成员的功能提供一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The FASEB Journal 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

6243

审稿时长

3 months

期刊介绍： The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.