Chengfeng Gao , Man Zhu , Yang Xu , Yali Wang , Dejuan Sun , Hua Li , Lixia Chen
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引用次数: 0
Abstract
Research on the aerial parts of Aconitum gymnandrum Maxim. led to identifying three undescribed diterpenoid alkaloids gymnaconitines H-J (1–3), along with eleven known analogues (4–14). Based on 1D/2D NMR and HRESIMS, the structures of these compounds were successfully determined. Additionally, the inhibitory effects of all compounds on NO production were evaluated in lipopolysaccharide-induced RAW264.7 cells. It is noteworthy that compounds 1, 3 and 6 demonstrated significant inhibitory effects, showing IC50 values of 10.36 ± 1.02 μM, 12.87 ± 1.11 μM, and 19.67 ± 1.29 μM, respectively. Using target screening and molecular docking technology, it is hypothesized that compound 1 may play an anti-inflammatory role by combining with Flamin-B.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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