Tissue Engineering and Regenerative Medicine: Perspectives and Challenges

IF 10.7 Q1 MEDICINE, RESEARCH & EXPERIMENTAL MedComm Pub Date : 2025-04-24 DOI:10.1002/mco2.70192
Van T. Hoang, Quyen Thi Nguyen, Trang Thi Kieu Phan, Trang H. Pham, Nhung Thi Hong Dinh, Le Phuong Hoang Anh, Lan Thi Mai Dao, Van Dat Bui, Hong-Nhung Dao, Duc Son Le, Anh Thi Lan Ngo, Quang-Duong Le, Liem Nguyen Thanh
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Abstract

From the pioneering days of cell therapy to the achievement of bioprinting organs, tissue engineering, and regenerative medicine have seen tremendous technological advancements, offering solutions for restoring damaged tissues and organs. However, only a few products and technologies have received United States Food and Drug Administration approval. This review highlights significant progress in cell therapy, extracellular vesicle-based therapy, and tissue engineering. Hematopoietic stem cell transplantation is a powerful tool for treating many diseases, especially hematological malignancies. Mesenchymal stem cells have been extensively studied. The discovery of induced pluripotent stem cells has revolutionized disease modeling and regenerative applications, paving the way for personalized medicine. Gene therapy represents an innovative approach to the treatment of genetic disorders. Additionally, extracellular vesicle-based therapies have emerged as rising stars, offering promising solutions in diagnostics, cell-free therapeutics, drug delivery, and targeted therapy. Advances in tissue engineering enable complex tissue constructs, further transforming the field. Despite these advancements, many technical, ethical, and regulatory challenges remain. This review addresses the current bottlenecks, emphasizing novel technologies and interdisciplinary research to overcome these hurdles. Standardizing practices and conducting clinical trials will balance innovation and regulation, improving patient outcomes and quality of life.

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组织工程与再生医学:展望与挑战
从细胞治疗的先驱时代到生物打印器官的成就,组织工程和再生医学取得了巨大的技术进步,为修复受损组织和器官提供了解决方案。然而,只有少数产品和技术获得了美国食品和药物管理局的批准。本文综述了细胞治疗、细胞外囊泡治疗和组织工程方面的重大进展。造血干细胞移植是治疗多种疾病,特别是血液系统恶性肿瘤的有力工具。间充质干细胞已被广泛研究。诱导多能干细胞的发现彻底改变了疾病建模和再生应用,为个性化医疗铺平了道路。基因治疗是治疗遗传性疾病的一种创新方法。此外,基于细胞外囊泡的治疗已经成为一颗冉冉升起的新星,在诊断、无细胞治疗、药物输送和靶向治疗方面提供了有前途的解决方案。组织工程的进步使复杂的组织结构成为可能,进一步改变了这一领域。尽管取得了这些进步,但仍然存在许多技术、伦理和监管方面的挑战。这篇综述解决了当前的瓶颈,强调了克服这些障碍的新技术和跨学科研究。标准化实践和开展临床试验将平衡创新和监管,改善患者的治疗效果和生活质量。
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CiteScore
6.70
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0.00%
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审稿时长
10 weeks
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