{"title":"Interfering with GPX4 degradation","authors":"Jing Li, Yuhan Zhou, Weimin Wang","doi":"10.1038/s41589-025-01873-9","DOIUrl":null,"url":null,"abstract":"Inducing tumoral ferroptosis is a potential strategy for augmenting cancer immunotherapy. A recent study reveals that PSAT1-mediated GPX4 hydroxylation in response to IFNγ stimulation impedes tumoral ferroptosis, whereas disrupting the PSAT1–GPX4 interaction can improve the efficacy of cancer immunotherapy.","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"21 9","pages":"1308-1309"},"PeriodicalIF":13.7000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature chemical biology","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41589-025-01873-9","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Inducing tumoral ferroptosis is a potential strategy for augmenting cancer immunotherapy. A recent study reveals that PSAT1-mediated GPX4 hydroxylation in response to IFNγ stimulation impedes tumoral ferroptosis, whereas disrupting the PSAT1–GPX4 interaction can improve the efficacy of cancer immunotherapy.
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