Revisiting the complex interactions in nocturnal polyuria: insights on OSA, ADH and ANP

IF 14.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2025-04-25 DOI:10.1038/s41585-025-01028-4
Yu-Hsiang Lin, Kuo-Jen Lin, Chun-Te Wu
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重新审视夜间多尿的复杂相互作用:OSA, ADH和ANP的见解
值得注意的是,患有良性前列腺增生症(BPH)的男性也会出现类似的恶性循环。良性前列腺增生引起的膀胱出口梗阻会导致膀胱压力升高、膀胱顺应性受损,最终导致夜尿2。在这种情况下,ADH 分泌受损和 ANP 活性增强的双重作用可能会使治疗方案变得复杂。在临床实践中,ADH 类似物(如去氨加压素)常用于解决 ADH 缺乏引起的夜间多尿问题。我们的假设是,ANP 可拮抗 OSA 患者体内 ADH 驱动的水重吸收4 ,这一假设从机理上揭示了所报道的治疗阻力3。将 ANP 测量纳入临床评估可完善夜间多尿症的治疗模式。
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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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