Radiolabeling lipoproteins to study and manage disease

IF 7.6 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Journal of Nuclear Medicine and Molecular Imaging Pub Date : 2025-04-28 DOI:10.1007/s00259-025-07281-4

Carlos Pérez-Medina, Edward A. Fisher, Zahi A. Fayad, Willem J. M. Mulder, Abraham J. P. Teunissen

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Abstract

Purpose

Lipoproteins are endogenous nanoparticles with essential roles in lipid transport and inflammation. Lipoproteins are also valuable in diagnosing and treating disease. For instance, certain lipoproteins are overexpressed in patients with atherosclerotic cardiovascular disease, and reconstituted lipoproteins have been extensively used for drug delivery. Radiolabeling has proven an especially powerful approach for studying and therapeutically exploiting lipoproteins. This review details how radiochemistry and nuclear imaging can facilitate the study of lipoproteins in health and disease. Among other topics, we discuss approaches for radiolabeling lipoproteins and detail how these have helped advance our understanding of lipoprotein biology and the diagnosis and treatment of diseases, including atherosclerosis, cancer, and hypercholesteremia.

Methods

We performed an extensive literature search on all peer-reviewed studies involving radiolabeled lipoproteins and selected representative examples to provide a high-level overview of the most important discoveries and technological advancements.

Results

More than 200 peer-reviewed papers involved radiolabeled lipoproteins, spanning mechanistic, diagnostic, and therapeutic studies across a wide range of diseases.

Conclusion

Radiolabeling has been critical in advancing our understanding of lipoprotein biology and leveraging these nanomaterials for diagnosing and treating disease.

Graphical Abstract

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对脂蛋白进行放射性标记以研究和管理疾病

目的脂蛋白是内源性纳米颗粒，在脂质转运和炎症中起重要作用。脂蛋白在诊断和治疗疾病方面也很有价值。例如，某些脂蛋白在动脉粥样硬化性心血管疾病患者中过度表达，重组脂蛋白已被广泛用于药物传递。放射性标记已被证明是研究和治疗利用脂蛋白的一种特别有效的方法。本文详细介绍了放射化学和核成像如何促进脂蛋白在健康和疾病中的研究。在其他主题中，我们讨论了脂蛋白的放射性标记方法，并详细介绍了这些方法如何帮助我们提高对脂蛋白生物学的理解以及对疾病（包括动脉粥样硬化、癌症和高胆固醇血症）的诊断和治疗。方法我们对所有涉及放射性标记脂蛋白的同行评审研究进行了广泛的文献检索，并选择了代表性的例子，以提供最重要的发现和技术进步的高层次概述。结果200多篇同行评议的论文涉及放射性标记脂蛋白，涵盖了广泛疾病的机制、诊断和治疗研究。结论放射性标记技术对提高我们对脂蛋白生物学的认识和利用这些纳米材料诊断和治疗疾病至关重要。图形抽象

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来源期刊

European Journal of Nuclear Medicine and Molecular Imaging 医学-核医学

CiteScore

15.60

自引率

9.90%

发文量

392

审稿时长

3 months

期刊介绍： The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.