Responses in Xenopus to the thymus independent antigen polyvinylpyrrolidone (PVP) and its haptenated derivative, trinitrophenylated PVP (TNP-PVP)

Cell differentiation Pub Date : 1988-04-01 DOI:10.1016/0045-6039(88)90074-7

Richard H. Clothier , Linda Kandola , Meena Mirchandani , Andrew Ellis , Paul Wood , Zoe Last , Michael Balls , Laurens N. Ruben

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引用次数: 4

Abstract

Xenopus laevis (the South African clawed toad) can respond to thymus dependent (TD) and thymus independent (TI) antigens. However, the response to trinitrophenylated Ficoll (TNP-Ficoll), a TI-2 antigen in mammals, is thymus dependent in Xenopus. Polyvinylpyrrolidone (PVP), classed as a TI antigen in mammals, is also a TI antigen in Xenopus, but responses to PVP and TNP-PVP are thymus regulated. As with TNP-Ficoll, capacity to respond to TNP-PVP diminishes during metamorphosis, and tolerance can be induced via the stimulation of TD suppression with trinitrobenzene sulphonic acid. Animals treated with N-methyl-N-nitrosourea and adult-thymectomised Xenopus, which lack certain TD responses, can nevertheless respond to TNP-PVP. Based on this and other information, it is concluded that TNP-PVP should be classed as a TI-2 antigen in Xenopus.

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非洲爪蟾对胸腺非依赖性抗原聚乙烯吡咯烷酮(PVP)及其半化衍生物三硝基苯化PVP (TNP-PVP)的反应

非洲爪蟾(Xenopus laevis，南非爪蟾)可以对胸腺依赖性(TD)和胸腺非依赖性(TI)抗原产生反应。然而，非洲爪蟾对哺乳动物TI-2抗原三硝基苯化Ficoll (TNP-Ficoll)的反应依赖于胸腺。聚乙烯吡咯烷酮(PVP)在哺乳动物中属于TI抗原，在爪蟾中也是TI抗原，但对PVP和TNP-PVP的反应是由胸腺调节的。与TNP-Ficoll一样，对TNP-PVP的反应能力在变态过程中减弱，可以通过三硝基苯磺酸刺激TD抑制诱导耐受性。用n -甲基-n -亚硝基脲治疗的动物和去胸腺的成年爪蟾，缺乏一定的TD反应，但仍然可以对TNP-PVP产生反应。综上所述，认为TNP-PVP在爪蟾中属于TI-2抗原。

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Cell differentiation

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