Muscular dysgenesis in fowl: ultrastructural study of skeletal muscles in the crooked neck dwarf (cn/cn) mutant.

M Kieny, A M Boutineau, M P Pautou, P F Goetinck
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Abstract

In vivo evolutive aspects of muscular dysgenesis were studied in normal and crooked neck dwarf (cn/cn) 7.5- to 20-day chick embryos. Wing, leg and breast muscles were processed for electron microscopy. It appears that the effects of the gene cn are expressed in the multinucleated cells as fine structural aberrations. Dilatation of the sarcotubular system, partial loss of the contractile elements and malorganization of the myofibrils are the major anomalies observed from day 7.5 to 18 of incubation. These changes do not constitute an abrupt phenomenon. Normal and diseased multinucleated cells always coexist in the same muscle specimen; however the frequency of the pathological cells augments with time. At the end of the incubation period, the poorly organized muscle tissue contains only morbid muscle cells. Phagocytosis or autolysis are absent.

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家禽肌肉发育不良:弯曲颈侏儒突变体骨骼肌的超微结构研究。
在7.5 ~ 20天的正常和弯曲颈侏儒鸡胚胎中研究了肌肉发育不良的体内进化方面。对翅膀、腿和胸部肌肉进行电子显微镜处理。基因cn的作用在多核细胞中表现为精细结构畸变。肌管系统的扩张,部分收缩元素的丧失和肌原纤维的组织失调是从孵化第7.5天到18天观察到的主要异常。这些变化并不构成突然的现象。正常和病变的多核细胞总是在同一肌肉标本中共存;病理细胞的频率随时间增加而增加。在潜伏期结束时,组织不良的肌肉组织只含有病态的肌肉细胞。没有吞噬或自溶作用。
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