The influence of phenobarbital on the pharmacokinetics of propranolol in pregnancy.

Biological research in pregnancy and perinatology Pub Date : 1987-01-01

A Hoffmann-Traeger, G Peiker, R Glöckner, I Wittmann, A Balogh, L Henschel

引用次数: 0

Abstract

In 7 pregnant hypertensive patients the elimination half-life of propranolol was enhanced to 6.1 +/- 1.2 h in comparison to 4.4 +/- 0.4 in 9 nonpregnant females. In 8 out of 11 pregnant hypertensive patients in the 29th week of gestation treated with 90 mg phenobarbital daily for at least 7 days before starting propranolol therapy, the half-life of propranolol was 3.1 +/- 0.4 h only. This significant difference between pregnant women with and without phenobarbital pretreatment is discussed as enzyme induction by phenobarbital.

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苯巴比妥对妊娠期心得安药动学的影响。

在7例妊娠高血压患者中，心得安的消除半衰期延长至6.1 +/- 1.2 h，而在9例未妊娠女性中则为4.4 +/- 0.4 h。11例妊娠29周妊娠高血压患者中，有8例在开始普萘洛尔治疗前每日服用90 mg苯巴比妥至少7天，普萘洛尔的半衰期仅为3.1±0.4 h。经苯巴比妥和未经苯巴比妥预处理的孕妇之间的这种显著差异被认为是苯巴比妥对酶的诱导作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological research in pregnancy and perinatology

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