{"title":"In vitro activity of ciprofloxacin against methicillin-susceptible and methicillin-resistant staphylococci.","authors":"B Gahrn-Hansen, P Søgaard, M Arpi","doi":"10.1007/BF02014254","DOIUrl":null,"url":null,"abstract":"<p><p>Ciprofloxacin was found to be active against selected strains of methicillin-resistant as well as methicillin-susceptible Staphylococcus aureus and Staphylococcus epidermidis, having minimal inhibitory concentrations less than 0.8 micrograms/ml with inocula of approximately 10(4) CFU/ml. When killing kinetic studies were done with inocula of approximately 10(6) CFU/ml and various ciprofloxacin concentrations, the killing effect was low (less than 3 log10 in 6 h) and regrowth of the culture was seen after 24 h in at least one Staphylococcus aureus strain. After 48 h incubation, mutants with MICs eightfold that of the parental strain had grown to a number of approximately 10(10) CFU/ml.</p>","PeriodicalId":11958,"journal":{"name":"European Journal of Clinical Microbiology","volume":"6 5","pages":"581-4"},"PeriodicalIF":0.0000,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02014254","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Clinical Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF02014254","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Ciprofloxacin was found to be active against selected strains of methicillin-resistant as well as methicillin-susceptible Staphylococcus aureus and Staphylococcus epidermidis, having minimal inhibitory concentrations less than 0.8 micrograms/ml with inocula of approximately 10(4) CFU/ml. When killing kinetic studies were done with inocula of approximately 10(6) CFU/ml and various ciprofloxacin concentrations, the killing effect was low (less than 3 log10 in 6 h) and regrowth of the culture was seen after 24 h in at least one Staphylococcus aureus strain. After 48 h incubation, mutants with MICs eightfold that of the parental strain had grown to a number of approximately 10(10) CFU/ml.
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