[Embryotoxic and teratogenic effects of Pharmachim's lincomycin hydrochloride].

Abstract

Tested was the teratogenic and embryotoxic action of linkomycin hydrochloride with both placental and nonplacental animals. It was found that when applied twice, orally, to albino rats on the 4th day of pregnancy at the rate of 250 mg/kg body mass (=5 ED50), and once to chick embryos at 50 mg per egg the antibiotic raised the percent of pre- and postimplantation loss of embryos. In a series of applications (oral) from the 3rd up to the 19th day at 50 mg/kg body mass to rats as well as in a single application to chick embryos at 10, 20, and 50 mg per egg linkomycin showed no teratogenic effects.