{"title":"Aspirin, anticoagulants, and hemorrhagic conversion of ischemic infarction: hypothesis and implications.","authors":"M Fisher","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic. Little is known of any potential added risk of aspirin plus anticoagulation for such hemorrhagic transformation. A patient is reported who sustained a cerebral infarction from carotid artery disease and was treated with aspirin. Anticoagulation was begun and aspirin discontinued when the patient experienced a transient ischemic attack. Despite good control of anticoagulation, the patient sustained a hemorrhage at the site of infarction. The prolonged effects of aspirin combined with anticoagulants may have potentiated the conversion of an ischemic to a hemorrhagic infarction. Caution is advised when using anticoagulation immediately following aspirin therapy in patients with cerebral infarction.</p>","PeriodicalId":77682,"journal":{"name":"Bulletin of clinical neurosciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of clinical neurosciences","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic. Little is known of any potential added risk of aspirin plus anticoagulation for such hemorrhagic transformation. A patient is reported who sustained a cerebral infarction from carotid artery disease and was treated with aspirin. Anticoagulation was begun and aspirin discontinued when the patient experienced a transient ischemic attack. Despite good control of anticoagulation, the patient sustained a hemorrhage at the site of infarction. The prolonged effects of aspirin combined with anticoagulants may have potentiated the conversion of an ischemic to a hemorrhagic infarction. Caution is advised when using anticoagulation immediately following aspirin therapy in patients with cerebral infarction.