Linkage analysis and multi-point mapping of 11p markers.

Abstract

Loci assigned to the short arm of chromosome 11 include insulin, oncogene c-Ha-ras-1, ADJ, beta-globin, parathyroid hormone, calcitonin, and catalase. However, the order of these loci is not clear because two major datasets (UTAH, White et al, 1985, and HOPKINS, Fearon et al, 1984) give conflicting results when analyzed separately. Also, the loci in this region exhibit an unusual sex difference in recombination in that more recombination is seen in males than females. For our analyses, we used both datasets for pair-wise and multi-point mapping of the llp markers.