Morphometric Study of Cauliflower Collagen Fibrils in Dermatosparaxis of the Calves

Gérald E. Piérard, Trinh Lê, Jean-François Hermanns, Betty V. Nusgens, Charles M. Lapière
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引用次数: 25

Abstract

The abnormal cauliflower collagen fibrils present in the skin of dermatosparactic calves were studied by electron microscopy and computerized image analysis.

The structure of the fibrils is heterogeneous and varies according to their location in the dermis. Cauliflower fibrils seems due to a defect in the lateral cohesion between the constitutive procollagen polymers. This is associated with the presence of a non-collageneous material larger than the aminopropeptide surrounding the procollagen polymers, while the volume occupied by procollagen in each fibril is comparable to that of collagen in normal fibrils.

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犊牛皮间隙花椰菜胶原原纤维形态计量学研究
用电子显微镜和计算机图像分析方法研究了皮肤间隙小牛皮肤中存在的异常花椰菜胶原原纤维。原纤维的结构是异质的,并根据它们在真皮层中的位置而变化。花椰菜原纤维似乎是由于本构性前胶原聚合物之间的横向内聚缺陷。这与前胶原聚合物周围存在比氨基前肽更大的非胶原物质有关,而每根原纤维中前胶原所占的体积与正常原纤维中的胶原相当。
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