The effect of long-term almitrine therapy on sleep hypoxaemia in patients with chronic airways obstruction.

J L Racineux, N Meslier, P Hubert
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Abstract

Sleep hypoxaemia was investigated in 11 patients. The patients were randomly assorted to receive almitrine bismesylate therapy or identical placebo tablets. Almitrine therapy was associated with an increase of daytime PaO2, mean SaO2 awake and during sleep, and less time when SaO2 fell below 90% during sleep. The number of desaturation episodes and lowest SaO2 were unaffected.

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长期almitine治疗慢性气道阻塞患者睡眠低氧血症的疗效观察。
对11例患者进行睡眠低氧血症调查。患者被随机分组接受双甲磺酸钠治疗或相同的安慰剂片。Almitrine治疗与白天PaO2、醒时和睡眠时平均SaO2升高以及睡眠时SaO2低于90%的时间减少有关。去饱和发作次数和最低SaO2不受影响。
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