{"title":"The acute effects of pergolide in cyclical oedema.","authors":"J B Young, M A Brownjohn, C Chapman, M R Lee","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The acute effects of a single 10 micrograms dose of a new dopamine agonist, pergolide, were investigated in 6 healthy women and 6 women with cyclical oedema. There was a prompt and significant reduction in mean plasma prolactin concentrations with maximum suppression occurring at 4 hours in both groups. However, the prolactin suppression was significantly less in the women with cyclical oedema. This is further evidence for a prolactin disturbance in cyclical oedema, and consistent with the proposal that reduced dopaminergic tone may be an important abnormality in the disorder.</p>","PeriodicalId":19862,"journal":{"name":"Pharmatherapeutica","volume":"4 9","pages":"551-4"},"PeriodicalIF":0.0000,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmatherapeutica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The acute effects of a single 10 micrograms dose of a new dopamine agonist, pergolide, were investigated in 6 healthy women and 6 women with cyclical oedema. There was a prompt and significant reduction in mean plasma prolactin concentrations with maximum suppression occurring at 4 hours in both groups. However, the prolactin suppression was significantly less in the women with cyclical oedema. This is further evidence for a prolactin disturbance in cyclical oedema, and consistent with the proposal that reduced dopaminergic tone may be an important abnormality in the disorder.
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