Plasma levels and urinary vitamin C excretion in schizophrenic patients.

Human nutrition. Clinical nutrition Pub Date : 1986-11-01
K Suboticanec, V Folnegović-Smalc, R Turcin, B Mestrović, R Buzina
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Abstract

Vitamin C status was determined in schizophrenic subjects using fasting plasma levels and the urinary dose response after an oral load of 1.0 g ascorbic acid. The study was carried out in 20 schizophrenic patients and 15 controls with the diagnosis of neurosis who were on the same hospital diet for at least 2 months. The schizophrenic subjects had significantly lower fasting plasma vitamin C levels (P less than 0.05) and 6-h urinary vitamin C excretion after an ascorbic acid load test (P less than 0.01). Since urinary vitamin C excretion in both groups was significantly associated with differences in fasting vitamin C plasma levels (P less than 0.001), a new group of 15 schizophrenics and 15 controls was supplemented with 70 mg of ascorbic acid daily for 4 weeks in order to optimize and standardize their vitamin C plasma levels before the ascorbic acid loading test. The results showed that after 4 weeks of supplementation the average fasting plasma vitamin C levels were almost identical in both examined groups, but the urinary vitamin C excretion was again significantly lower in schizophrenic patients (P less than 0.05). These results are in agreement with the hypothesis that schizophrenia may be associated with impaired ascorbic acid metabolism.

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精神分裂症患者血浆水平和尿中维生素C排泄。
采用空腹血浆水平和口服1.0 g抗坏血酸后尿液剂量反应测定精神分裂症患者的维生素C状态。这项研究是在20名精神分裂症患者和15名被诊断为神经症的对照组中进行的,他们在同一医院饮食至少2个月。抗坏血酸负荷试验后,精神分裂症患者空腹血浆维生素C水平显著降低(P < 0.05), 6 h尿维生素C排泄量显著降低(P < 0.01)。由于两组患者尿中维生素C排泄量与空腹维生素C血浆水平差异显著相关(P < 0.001),因此,新设一组15名精神分裂症患者和15名对照者,连续4周每天补充70 mg抗坏血酸,以优化和规范他们在抗坏血酸负荷试验前的维生素C血浆水平。结果显示,在补充4周后,两组患者的平均空腹血浆维生素C水平几乎相同,但精神分裂症患者的尿维生素C排泄量再次显著降低(P < 0.05)。这些结果与精神分裂症可能与抗坏血酸代谢受损有关的假设一致。
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