F Lapicque, P Netter, C Monot, B Bannwarth, M S Maknassi, R J Royer
{"title":"[Determination of protein binding of drugs using equilibrium dialysis. Influence of volume displacement caused by osmotic pressure].","authors":"F Lapicque, P Netter, C Monot, B Bannwarth, M S Maknassi, R J Royer","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>By the determination of the free concentration of a drug using the equilibrium dialysis method, a volume shift could be observed, inducing a dilution of the protein medium. The value of this volume shift varies with the plasmatic sample and could produce a misdetermination of the free fraction which could be important, essentially for the drugs strongly bound to proteins.</p>","PeriodicalId":14817,"journal":{"name":"Journal de pharmacologie","volume":"17 3","pages":"295-300"},"PeriodicalIF":0.0000,"publicationDate":"1986-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal de pharmacologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
By the determination of the free concentration of a drug using the equilibrium dialysis method, a volume shift could be observed, inducing a dilution of the protein medium. The value of this volume shift varies with the plasmatic sample and could produce a misdetermination of the free fraction which could be important, essentially for the drugs strongly bound to proteins.
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