[Chemotactic response of human polynuclear neutrophils after in vivo administration of spiramycin].

Abstract

The chemotactic response of polymorphonuclear leukocytes using the agarose method, has been studied in six healthy volunteers, immediately prior and after a 5-day oral administration of spiramycin, 6 million units per day. The influence of spiramycin proved to be small as the directed and spontaneous migration were decreased by 21% and 18% respectively. Despite the fact that spiramycin can penetrate into leukocytes, these results indicate that no clinically relevant alterations of chemotaxis are likely under therapeutic conditions.