{"title":"Chemotaxis of porcine neutrophils under agarose.","authors":"G S Smith, J H Lumsden, B P Wilcock","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The standardization of pig neutrophil chemotaxis under agarose is described. The mean chemotactic index for pig neutrophils from six pigs measured over four days was 1.29. Comparative studies of human and pig neutrophil chemotaxis under agarose revealed a lower chemotactic index for pig neutrophils (mean of 1.18) compared to human neutrophils (mean of 2.43). The results suggest that this is due to differences intrinsic to human and pig neutrophils. In vitro pig neutrophil chemotaxis was measured in normal pigs and in pigs following experimental Salmonella typhimurium infection. Significant alterations in chemotaxis were not evident one and seven days postinfection.</p>","PeriodicalId":9546,"journal":{"name":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","volume":"49 1","pages":"43-9"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236114/pdf/compmed00001-0045.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of comparative medicine : Revue canadienne de medecine comparee","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The standardization of pig neutrophil chemotaxis under agarose is described. The mean chemotactic index for pig neutrophils from six pigs measured over four days was 1.29. Comparative studies of human and pig neutrophil chemotaxis under agarose revealed a lower chemotactic index for pig neutrophils (mean of 1.18) compared to human neutrophils (mean of 2.43). The results suggest that this is due to differences intrinsic to human and pig neutrophils. In vitro pig neutrophil chemotaxis was measured in normal pigs and in pigs following experimental Salmonella typhimurium infection. Significant alterations in chemotaxis were not evident one and seven days postinfection.
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