Ali M. Emran, Thomas E. Boothe, Ronald D. Finn, Manhar M. Vora, Paresh J. Kothari, J. Thomas Wooten
{"title":"Optimized production of high specific activity [11C]urea","authors":"Ali M. Emran, Thomas E. Boothe, Ronald D. Finn, Manhar M. Vora, Paresh J. Kothari, J. Thomas Wooten","doi":"10.1016/0020-708X(85)90046-8","DOIUrl":null,"url":null,"abstract":"<div><p>Use of [<sup>11</sup>C]urea as an intermediate for the preparation of “no-carrier-added” radiopharmaceuticals required optimization of synthetic parameters. A procedure has been developed to produce [<sup>11</sup>C]urea from “no-carrier-added” <sup>11</sup>CN<sup>−</sup> within 16 ± 1 min from end of bombardment (EOB) with a radiochemical yield of 95.0 ± 2.5%.</p></div>","PeriodicalId":22517,"journal":{"name":"The International journal of applied radiation and isotopes","volume":"36 9","pages":"Pages 739-740"},"PeriodicalIF":0.0000,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-708X(85)90046-8","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of applied radiation and isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020708X85900468","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
Use of [11C]urea as an intermediate for the preparation of “no-carrier-added” radiopharmaceuticals required optimization of synthetic parameters. A procedure has been developed to produce [11C]urea from “no-carrier-added” 11CN− within 16 ± 1 min from end of bombardment (EOB) with a radiochemical yield of 95.0 ± 2.5%.
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