{"title":"Linkage analysis for psychiatric disorders. I. Basic concepts.","authors":"B K Suarez, N J Cox","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Within the last decade linkage analysis has become one of the most useful tools in the human genetics arsenal and is beginning to make substantial contributions in all areas of medicine. Its increasing popularity is a direct result of the burgeoning number of polymorphic markers that are now mapped to specific chromosomal locations. Within the near future the entire human genome is likely to be saturated. This paper is intended as an introduction to linkage analysis for non-geneticists. Basic methodological approaches, along with their strengths, weaknesses and assumptions are reviewed. A subsequent paper will critically review methodological difficulties in the application of linkage analysis to the psychiatric disorders.</p>","PeriodicalId":77773,"journal":{"name":"Psychiatric developments","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatric developments","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Within the last decade linkage analysis has become one of the most useful tools in the human genetics arsenal and is beginning to make substantial contributions in all areas of medicine. Its increasing popularity is a direct result of the burgeoning number of polymorphic markers that are now mapped to specific chromosomal locations. Within the near future the entire human genome is likely to be saturated. This paper is intended as an introduction to linkage analysis for non-geneticists. Basic methodological approaches, along with their strengths, weaknesses and assumptions are reviewed. A subsequent paper will critically review methodological difficulties in the application of linkage analysis to the psychiatric disorders.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
