{"title":"Effect of the Tc-Nitrido group on the behaviour of 99mTc-radiopharmaceuticals","authors":"John Baldas, John Bonnyman","doi":"10.1016/0020-708X(85)90247-9","DOIUrl":null,"url":null,"abstract":"<div><p>The preparation of the <sup>99<em>m</em></sup>TcN-complexes of gluconate, EHDP, HIDA and PIPIDA by substitution reactions of <sup>99<em>m</em></sup>TcNCl<sub>4</sub><sup>−</sup> is described. Studies of the distribution of these complexes in mice indicate that the presence of the Tc-nitrido group significantly alters the biological properties of the <sup>99<em>m</em></sup>Tc-complexes formed using these ligands. Results suggest that the <sup>99<em>m</em></sup>TcN-complexes of these ligands are labile and undergo some ligand exchange <em>in vivo</em>.</p></div>","PeriodicalId":22517,"journal":{"name":"The International journal of applied radiation and isotopes","volume":"36 12","pages":"Pages 919-923"},"PeriodicalIF":0.0000,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-708X(85)90247-9","citationCount":"35","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of applied radiation and isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020708X85902479","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 35
Abstract
The preparation of the 99mTcN-complexes of gluconate, EHDP, HIDA and PIPIDA by substitution reactions of 99mTcNCl4− is described. Studies of the distribution of these complexes in mice indicate that the presence of the Tc-nitrido group significantly alters the biological properties of the 99mTc-complexes formed using these ligands. Results suggest that the 99mTcN-complexes of these ligands are labile and undergo some ligand exchange in vivo.
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