Changes in norepinephrine and histamine in monkey spinal cords traumatized by weight drop and compression.

Central nervous system trauma : journal of the American Paralysis Association Pub Date : 1985-01-01 DOI:10.1089/cns.1985.2.61

A Kuruvilla, D R Theodore, J Abraham

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引用次数: 8

Abstract

Changes in norepinephrine and histamine levels in the spinal cord of monkeys at 1/2, 2, and 4 hours after 200 g cm of contusion injury, 50 g of compression injury, and 2 hours of decompression following 4 hours of compression were studied in the traumatized and an adjacent nontraumatized segment. Norepinephrine levels were elevated in the traumatized segment at 1/2, 2, and 4 hours after contusion injury and in the adjacent nontraumatized segment at 1/2 hour. Compression of 1/2 and 2 hours caused elevation of norepinephrine in both the traumatized and nontraumatized segments. On decompressing the values of norepinephrine reverted to near normal levels. Histamine content increased in the traumatized segment at 2 and 4 hours after contusion injury and in the adjacent nontraumatized segment at 2 hours. Compression injury did not change histamine levels, but decompression caused an increase. The possible influence of simultaneous changes in norepinephrine and histamine levels on the vessels following injury is discussed.

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体重下降和压迫损伤的猴子脊髓去甲肾上腺素和组胺的变化。

研究了猴子脊髓外伤和相邻非外伤节段在200 g cm挫伤、50 g压迫损伤和4小时后减压2小时时，去甲肾上腺素和组胺水平在1/2、2和4小时的变化。外伤节段的去甲肾上腺素水平在挫伤后1/2、2和4小时升高，邻近非外伤节段的去甲肾上腺素水平在半小时升高。压迫1/2和2小时导致创伤节段和非创伤节段去甲肾上腺素升高。减压后，去甲肾上腺素的值恢复到接近正常水平。挫伤后2小时和4小时损伤节段组胺含量升高，相邻非损伤节段组胺含量升高。压缩损伤不改变组胺水平，但减压引起组胺水平升高。本文讨论了损伤后去甲肾上腺素和组胺水平同时变化对血管的可能影响。

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Central nervous system trauma : journal of the American Paralysis Association

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