Acid mucopolysaccharide composition of human-heart valve

Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides Pub Date : 1965-11-01 DOI:10.1016/0926-6534(65)90007-2

Shinichiro Torii , Reza I. Bashey , Komei Nakao

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引用次数: 44

Abstract

1.
1. The content and fractional distribution of acid mucopolysaccharides in normal human-heart valves were studied.
2.
2. The acid mucopolysaccharide content was significantly different in the aortic, mitral and tricuspid valves in the young age group. The aortic valve contained the highest amount of acid mucopolysaccharide and the tricuspid had the least.
3.
3. The content of acid mucopolysaccharide decreased with age in these three valves. The decrease was most marked in the aortic valve and the tricuspid showed the least change.
4.
4. Three kinds of acid mucopolysaccharide, namely hyaluronic acid, chondroitin sulfate B and chondroitin sulfate A or C were found in these valves. Hyaluronic acid was the major component constituting approx. 60% of the total acid mucopolysaccharide.
5.
5. There was no remarkable change in the distribution of these three acid mucopolysaccharides during the aging process from 20 to 60 years or over.

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人体心脏瓣膜的酸性粘多糖组成

1.1. 研究了正常人心脏瓣膜中酸性粘多糖的含量和分级分布。青年组主动脉瓣、二尖瓣和三尖瓣酸性粘多糖含量差异有统计学意义。主动脉瓣中酸性粘多糖含量最高，三尖瓣中含量最低。酸性粘多糖的含量随年龄的增长而降低。主动脉瓣下降最明显，三尖瓣变化最小。在这些瓣膜中发现了三种酸性粘多糖，即透明质酸、硫酸软骨素B和硫酸软骨素A或C。透明质酸是其中的主要成分。总酸性粘多糖的60%。在20 ~ 60年以上的衰老过程中，这三种酸性粘多糖的分布没有显著变化。

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Biochimica et Biophysica Acta (BBA) - Mucoproteins and Mucopolysaccharides

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