H Birkedal-Hansen, C M Cobb, R E Taylor, H M Fullmer
{"title":"Serum inhibition of gingival collagenase.","authors":"H Birkedal-Hansen, C M Cobb, R E Taylor, H M Fullmer","doi":"10.1111/j.1600-0714.1974.tb01723.x","DOIUrl":null,"url":null,"abstract":"<p><p>Collagenases derived from bovine and human gingiva are inhibited effectively by serum. In bovine and human serum fractionated by gel chromatography, alpha2-macroglobulin is the only significant inhibitor of gingival collagenase. alpha11-Antitrypsin inhibited collagenase only in very high concentration and was several hundred-fold less effective than alpha2-macroglobulin. Inhibition of gingival collagenase with alpha2-macroglobulin is accompanied by the formation of an enzyme-inhibitor complex, which has retained no collagenolytic activity.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1974-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1974.tb01723.x","citationCount":"22","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/j.1600-0714.1974.tb01723.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 22
Abstract
Collagenases derived from bovine and human gingiva are inhibited effectively by serum. In bovine and human serum fractionated by gel chromatography, alpha2-macroglobulin is the only significant inhibitor of gingival collagenase. alpha11-Antitrypsin inhibited collagenase only in very high concentration and was several hundred-fold less effective than alpha2-macroglobulin. Inhibition of gingival collagenase with alpha2-macroglobulin is accompanied by the formation of an enzyme-inhibitor complex, which has retained no collagenolytic activity.
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