{"title":"An investigation of the tremorgenic effects of oxotremorine and tremorine after stereotaxic injection into rat brain","authors":"B. Cox, D. Potkonjak","doi":"10.1016/0028-3908(69)90050-1","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of stereotaxic administration of tremorine and oxotremorine into four brain areas has been investigated using rats. Tremorine produced tremor significantly higher than control after administration into the globus pallidus, caudate nucleus, and substantia nigra. Oxotremorine produced tremor significantly higher than control only after injection into the substantia nigra. Dyflos injected into the caudate nucleus produced tremor. No change in the tremorgenic action of tremorine was observed after the simultaneous intracaudate injections of atropine and tremorine, and dyflos and tremorine. Intraperitoneal atropine reduced the tremorgenic action of an intracaudate injection of tremorine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90050-1","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900501","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 20
Abstract
The effect of stereotaxic administration of tremorine and oxotremorine into four brain areas has been investigated using rats. Tremorine produced tremor significantly higher than control after administration into the globus pallidus, caudate nucleus, and substantia nigra. Oxotremorine produced tremor significantly higher than control only after injection into the substantia nigra. Dyflos injected into the caudate nucleus produced tremor. No change in the tremorgenic action of tremorine was observed after the simultaneous intracaudate injections of atropine and tremorine, and dyflos and tremorine. Intraperitoneal atropine reduced the tremorgenic action of an intracaudate injection of tremorine.
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