W. Meier-Ruge M.D. , P.M. Lutterbeck M.D. , B. Herzog M.D. , R. Morger M.D. , R. Moser M.D. , A. Schärli M.D.
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引用次数: 240
Abstract
Rectal suction biopsies have been employed in 214 subjects suspected of having Hirschsprung's disease. By applying conventional histology and acetylcholinesterase (AChE) determinations, 66 (31%) cases were diagnosed as Hirschsprung's disease—all of which were surgically confirmed. The problem of unsatisfactory biopsy material was circumvented by exclusively assessing for AChE activity. Despite the normal paucity of ganglion cells within the lowest 3 cm of the rectum, excessive enzyme accumulation characteristic of Hirschsprung's disease paralleled the findings obtained from the classical narrowed aganglionic segment.
期刊介绍：
The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery. The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, pathology and surgical techniques, but also by attention to the unique emotional and physical needs of the young patient.
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