{"title":"Cholesterol esterification by transacylation in human and experimental atheromatous lesions","authors":"Y.H. Abdulla , C.C. Orton, C.W.M. Adams","doi":"10.1016/S0368-1319(68)80011-0","DOIUrl":null,"url":null,"abstract":"<div><p><em>In vitro</em> cholesterol esterification by either human or rabbit’s aorta in the presence of <em>β</em>-fatty acid-labelled lecithin appears to depend on a lecithin:cholesterol fatty acid (acyl) transferase. The activity of this enzyme increases in human fatty atherosclerotic lesions and in atherosclerotic aortas from cholesterol-fed rabbits. Activity decreases in fibrous and calcified human atherosclerotic lesions.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 967-973"},"PeriodicalIF":0.0000,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80011-0","citationCount":"58","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of atherosclerosis research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0368131968800110","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 58
Abstract
In vitro cholesterol esterification by either human or rabbit’s aorta in the presence of β-fatty acid-labelled lecithin appears to depend on a lecithin:cholesterol fatty acid (acyl) transferase. The activity of this enzyme increases in human fatty atherosclerotic lesions and in atherosclerotic aortas from cholesterol-fed rabbits. Activity decreases in fibrous and calcified human atherosclerotic lesions.
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