{"title":"The effects of strychnine on the inhibition of interneurons by glycine and γ-aminobutyric acid","authors":"R.A. Davidoff , M.H. Aprison , R. Werman","doi":"10.1016/0028-3908(69)90013-6","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of strychnine on the inhibition of spinal interneurons produced by glycine and GABA was studied by means of iontophoretic application from multibarrel electrodes. The actions of glycine were more effectively blocked by strychnine than were those of GABA. The data suggest that a non-competitive type of antagonism exists between strychnine and these inhibitory amino acids.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90013-6","citationCount":"86","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900136","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 86
Abstract
The effects of strychnine on the inhibition of spinal interneurons produced by glycine and GABA was studied by means of iontophoretic application from multibarrel electrodes. The actions of glycine were more effectively blocked by strychnine than were those of GABA. The data suggest that a non-competitive type of antagonism exists between strychnine and these inhibitory amino acids.
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