{"title":"Suppressive effect of tetrabenazine on the development of tolerance to morphine and its reversal by DOPA","authors":"H. Takagi, H. Kuriki","doi":"10.1016/0028-3908(69)90014-8","DOIUrl":null,"url":null,"abstract":"<div><p>When repeated daily administrations of tetrabenazine were given 2 hr before daily injection of morphine in mice, the development of tolerance to morphine analgesia was markedly suppressed. This suppressive effect was antagonized by repeated administrations of DOPA. These findings suggest that catecholamines might be involved in the development of tolerance to morphine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1969-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90014-8","citationCount":"19","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 19
Abstract
When repeated daily administrations of tetrabenazine were given 2 hr before daily injection of morphine in mice, the development of tolerance to morphine analgesia was markedly suppressed. This suppressive effect was antagonized by repeated administrations of DOPA. These findings suggest that catecholamines might be involved in the development of tolerance to morphine.
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