{"title":"Factors affecting the rate of disappearance of amphetamine in rats","authors":"A. Groppetti, E. Costa","doi":"10.1016/0028-3908(69)90041-0","DOIUrl":null,"url":null,"abstract":"<div><p>The rate of disappearance of amphetamine is faster in male adult Sprague-Dawley rats than in adult females. Estradiol (0·8 mg/kg s.c. for 16 days) slow down the rate ofd-amphetamine disappearance in adult male rats. The half-life (T12) ofd-amphetamine in young male rats is greater than in adult male or female rats. Pretreatment of rats with either phenobarbital or 3-methylcholanthrene in doses sufficient to decrease theT<sub>12</sub> of hexobarbital and zoxazolamine does not change the tissue levels ofd-amphetamine. Diphenylhydantoin, another inducer of liver microsomal aromatic hydroxylase, does not increase and actually decreases the rate ofd-amphetamine disappearance.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":"8 3","pages":"Pages 209-215"},"PeriodicalIF":0.0000,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90041-0","citationCount":"62","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390869900410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 62
Abstract
The rate of disappearance of amphetamine is faster in male adult Sprague-Dawley rats than in adult females. Estradiol (0·8 mg/kg s.c. for 16 days) slow down the rate ofd-amphetamine disappearance in adult male rats. The half-life (T12) ofd-amphetamine in young male rats is greater than in adult male or female rats. Pretreatment of rats with either phenobarbital or 3-methylcholanthrene in doses sufficient to decrease theT12 of hexobarbital and zoxazolamine does not change the tissue levels ofd-amphetamine. Diphenylhydantoin, another inducer of liver microsomal aromatic hydroxylase, does not increase and actually decreases the rate ofd-amphetamine disappearance.
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